The effects of triiodothyronine on energy metabolism and myocardial protection
CHEN Qun-qing
CHEN Yan-chun
SUN Yao-chang
HU Hui-min
XU Zhi-fei
Abstract：Objective To observe the effects of triiodothyronine (T3) on myocardial energy metabolism and its protection of the myocardial cells in rat ischemic reperfusion myocardial model with different thyroid functions. Methods The rats were categorized into group A (with normal thyroid function) and group B (with hypothyroidism), and each group were divided into blank control group, ischemic group, control reperfusion group and T3 reperfusion group. An isolated rat heart working model was established. The contents of ATP, ADP, AMP in the myocardial tissue in different groups were measured by high-performance liquid chromatographic method. Results The contents of ATP, ADP, AMP declined markedly in hypothyroidism group (P<0.01). Thirty minutes of ischemic arrest induced significant decrease of, ATP, ADP and AMP contents both groups A and B, which further declined when the hearts were subjected to 20 min of reperfusion. However ,the content of ATP increased markedly in T3 reperfusion groups compared with the control reperfusion groups in both group A:[(1.03±0.02) vs (0.62±0.02) mmol/g and group B:[(0.85±0.02) vs (0.40±0.01)] mmol/g (P<0.01). Conclusions Hypothyroidism or ischemic reperfusion injury may badly damage myocardial energy metabolism; T3 coold markedly increase the capacities of synthesizing and reserving ATP, improving myocardial protection.
Keywords：triiodothyronineenergy metabolismmyocardial protectionthyroid functionischemic reperfusion injury
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 507-509 )