DOI: 10.1002/ame2.70109
Radiation emergency medical countermeasures:Current formulary,identified gaps,and future approaches
Wen-Bing Ma
Rong-Hua Yin
Guang-Ming Ren
Yin Zhang
Li-Juan Li
Wei Liu
Ting Chen
Wei Zhou
Mian Zu
Rong-Ling Yin
Xin-Di Shi
Lei Wang
Xiao-Ming Yang
Abstract：Radiological or nuclear accidents can lead to serious outcomes for individuals exposed to ionizing radiation, with health effects that are either acute or delayed, deterministic or stochastic, depending on the effective dose of exposure. Mechanistically, ionizing radiation can inflict damage either directly on DNA or through oxidative stress, which may trigger a cascade of damages to tissues and organs. The development of effective radiation medical countermeasures is an unmet need and should be a top priority in preparing for radiation emergencies. This paper aims to address the critical questions of whether current countermeasures are available, what additional measures are needed, and what actions can be taken to enhance the development of radiation medical countermeasures from a systematic perspective.
Keywords：acute radiation syndromeionizing radiationradiation injuryradiation medical countermeasures
Publication Date：2025-11-30
Online Publishing Date：2026-01-09(First online date of this platform, not the publication date of the document)
Pages：14( 2008-2021 )