DOI: 10.1002/ame2.12528
Targeting intracellular autophagic process for the treatment of post-stroke ischemia/reperfusion injury
Jun Hu
Zekai Hu
Jiayi Xia
Yeping Chen
Dennis Cordato
Qi Cheng
Jie Wang
Abstract：Cerebral ischemia/reperfusion (I/R) injury is an important pathophysiological condition of ischemic stroke that involves a variety of physiological and pathological cell death pathways, including autophagy, apoptosis, necroptosis, and phagoptosis, among which autophagy is the most studied. We have reviewed studies published in the past 5 years regarding the association between autophagy and cerebral I/R injury. To the best of our knowledge, this is the first review article summarizing potential candidates targeting autophagic pathways in the treatment of I/R injury post ischemic stroke. The findings of this review may help to better understand the pathogenesis and mechanisms of I/R events and bridge the gap between basic and translational research that may lead to the development of novel therapeutic approaches for I/R injury.
Keywords：autophagycerebral ischemiaischemia/reperfusion injurystroketreatment
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：16( 389-404 )