Diagnostic value of ultrasound-guided biopsy combined with multimodal ultrasound for breast cancer
Li Jun
Shao Liping
Zhang Yanchen
Gao Yuyan
Xu Xinglv
Huang Meng
Abstract：Objective To explore the diagnostic value of ultrasound-guided biopsy combined with multimodal ultrasound for breast cancer.Methods A total of 90 patients(90 breast lesions)with suspected malignant breast masses,who were diagnosed and treated in the First Affiliated Hospital of Anhui Medical University and its Dongcheng Campus from December 2024 to September 2025,were selected as the research subjects.All of them underwent conventional ultrasound,shear wave elastography(SWE),contrast-enhanced ultrasound(CEUS),and preoperative ultrasound-guided biopsy.Taking the postoperative pathological diagnosis results as the"gold standard",the research subjects were divided into the malignant mass group(n=32)and the benign mass group(n=58).The conventional two-dimensional ultrasound and CEUS characteristics of the two groups were compared,and the diagnostic values of preoperative ultrasound-guided puncture,SWE,and CEUS alone and in combination for breast cancer were analyzed.Results In terms of conventional ultrasound imaging features,the mass diameter,shape,aspect ratio,internal echo,marginal crab-foot or spicule-like changes,microcalcification,hyperechoic halo near the margin,and the abnormal features of axillary lymph nodes in the malignant mass group all showed greater changes than those in the benign mass group(all P<0.05).In terms of CEUS characteristics,there were greater proportions of centripetal enhancement,hyperenhancement,lesion enlargement after enhancement,and disordered vascular course within and around the lesion in the malignant mass group than in the benign mass group(all P<0.05).Compared with the single examination method,the combined examination had higher sensitivity,specificity,positive predictive value,negative predictive value and accuracy rate(all P<0.05),which were 96.88%,96.55%,93.93%,98.25%and 96.67%respectively.Conclusion Ultrasound-guided biopsy combined with SWE and CEUS can significantly improve the sensitivity and specificity of breast cancer diagnosis and has high clinical application value.
Keywords：Ultrasound-guided biopsyContrast-enhanced ultrasoundShear wave elastographyMultimodal ultrasoundBreast cancer
Publication Date：2025-10-20
Online Publishing Date：2026-03-25(First online date of this platform, not the publication date of the document)
Pages：6( 41-46 )