Evaluation of the clinical efficacy of drug eluting balloon in primary percutaneous coronary intervention based on optical coherence tomography
Pang Xuyao
Zhao Shixia
Song Xuelian
Liu Litian
Liu Qianpeng
Li Yingxiao
Zhang Feifei
Abstract：Objective To evaluate the clinical efficacy of drug coated balloon(DCB)in primary percutaneous coronary intervention(PPCI)based on optical coherence tomography(OCT).Methods We retrospectively analyzed data from patients who underwent PPCI with intraoperative OCT examination from February 2022 to December 2024.They were divided into the DCB group(n=15)and the drug-eluting stent(DES)group(n=40)according to the interventional treatment received.Relevant clinical data,coronary angiography,and OCT images were collected.Major adverse cardiovascular events(MACE)during the follow-up period were recorded,including cardiac death,recurrent acute myocardial infarction,target vessel revascularization,and bleeding events.Results There were no statistically significant differences in baseline clinical data between the DCB group and the DES group(P>0.05).Coronary angiography showed no significant differences in target vessels,preoperative and postoperative TIMI flow grades,thrombus aspiration,coronary thrombolysis,as well as device diameter and length between the two groups(P>0.05).Regarding coronary angiography parameters of target vessels,there were no statistically significant differences in preoperative reference vessel diameter,lesion length,or stenosis degree between the two groups(P>0.05).After PCI,the OCT minimum lumen area in the DCB group was smaller than that in the DES group,and the residual thrombus burden and incidence of dissection in the DCB group were higher than those in the DES group(P<0.05).The follow-up period was 28.0(18.0,29.5)months in the DCB group and 22.5(9.0,30.0)months in the DES group.During the follow-up period,1 patient in the DCB group had recurrent myocardial infarction and underwent target vessel revascularization,while 4 patients in the DES group underwent target vessel revascularization.Compared with patients without MACE,patients with MACE had higher postoperative residual thrombus burden,as well as higher incidences of dissection and intramural hematoma(P<0.05).Conclusion DCB can be safely and effectively used in PPCI for the treatment of lesions after adequate pretreatment,and OCT is helpful for identifying imaging features associated with postoperative MACE.
Keywords：Drug-coated balloonPrimary percutaneous coronary interventionOptical coherence tomographyDrug-eluting stent
Publication Date：2025-09-20
Online Publishing Date：2026-03-13(First online date of this platform, not the publication date of the document)
Pages：7( 52-58 )