Research progress on the association of platelet parameters and platelet derived ratios with acute ischemic stroke
Liu Rongrong
Yang Rongli
Zhu Shiguang
Lu Hailong
Liu Jian
Ping Lei
Sun Yong
Shi Yu
Zhai Yujia
Abstract：Acute ischemic stroke(AIS),a common type of stroke characterized by high recurrence rate and high disability rate,stands as one of the primary causes of death and disability in patients.Platelets play a pivotal role in the pathogenesis of AIS,being closely associated with multiple pathophysiological processes such as atherosclerosis,thrombosis and neuroinflammation.In recent years,studies have revealed that platelet parameters and related ratios hold significant clinical value in predicting the prognosis and outcome of AIS.This paper presents a comprehensive review of research advancements concerning a series of platelet derived ratios,including the platelet-lymphocyte ratio(PLR),platelet-neutrophil ratio(PNR),and mean platelet volume/platelet count ratio(MPV/PLT),in the context of AIS.By exploring the associations between these indicators and the occurrence,severity,poor prognosis and complications of AIS,this review aims to highlight their critical significance for formulating early treatment strategies and improving patient outcomes.
Keywords：Acute ischemic strokePlateletsAtherosclerosisInflammationOutcomeThrombolytic therapyThrombectomy
Publication Date：2025-06-20
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：8( 61-68 )