Research progress on the analysis of factors related to hemorrhagic transformation after endovascular treatment of acute anterior circulation cerebral infarction
Jia Xueqi
Liang Zhigang
Abstract：Acute ischemic stroke accounts for about 80%of all stroke cases.Among them,acute anterior circulation cerebral infarction,due to the blockage of the main blood supply arteries to the brain,leads to ischemia and hypoxia of brain tissue,with persistently high disability and mortality rates.The core of its treatment lies in the rapid opening of the occlusive blood vessels and the restoring of blood perfusion after the onset of the disease to rescue the ischemic penumbra.Endovascular treatment,as the preferred option for patients within 24 hours of onset,can effectively reduce the ischemia-reperfusion time of brain tissue and alleviate functional neurological damage.However,hemorrhagic transformation(HT)after endovascular treatment is a key factor affecting the prognosis of patients.Its occurrence is closely related to traditional factors such as age,early ASPECT score,and recanalization time.Moreover,recent studies have found that new factors such as magnetic resonance SWI manifestations,bridging thrombectomy strategies,intraoperative tirofiban and thrombolytic drug application,and TICI grading of vascular recanalization are also involved.This article systematically reviews the pathological mechanism,classification and related factors of hemorrhagic transformation after endovascular treatment of acute anterior circulation cerebral infarction,aiming to provide a reference for clinical screening of high-risk patients and for optimization of prevention and management strategies.
Keywords：Acute anterior circulation cerebral infarctionAcute anterior circulation large vessel occlusive strokeEndovascular treatmentHemorrhagic transformationRelated factors
Publication Date：2025-04-20
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：5( 76-80 )