Comparative analysis of endoscopic injection sclerotherapy and endoscopic variceal ligation in the treatment of esophageal varices bleeding in liver cirrhosis patients
Zhang Shuxian
Ren Ling
Liang Xuyang
Abstract：Objective To conduct a comparative analysis of the therapeutic efficacy and safety profiles between endoscopic injection sclerotherapy(EIS)and endoscopic variceal ligation(EVL)in managing acute esophageal variceal bleeding(EVB)secondary to liver cirrhosis.Methods Chinical data of patients with EVB in the First People's Hospital of Lianyungang from March 2020 to February 2023 were collected and retrospectively analyzed.Each patient was followed-up for six month after endoscopic therapy.The treatment effects in two groups were compared from efficient rate,rebleeding rate,complications and so on.Results The clinical data of 86 patients who were treated with EIS(n=49)or EVL(n=37)were qualified.In EIS group,41 patients(83.6%)were effective and 8 cases(16.4%)were ineffective.In EVL group,30 patients(81.1%)were effective and 7 cases(18.9%)were ineffective.There was no significant difference in elimination of varices between EVL group and EIS group(χ2=1.052,P>0.05).The early rebleeding rate(8.2%)in the EIS group was higher than that in the EVL group(8.1%),and the forward rebleeding rate in the EIS group(26.5%)was higher than that in the EVL group(21.6%),but both differences had no statistical significance(χ2=0.634,P=0.49;χ2=1.347,P=0.21,respectively).Differences in complications of fever(EIS group:14.3%vs EVL group:16.2%),eating choking(EIS group:6.1%vs EVL group:8.1%),and retrosternal pain(EIS group:12.2%vs EVL group:10.8%)had no statistical significance(χ2=1.523,P=0.17;χ2=0.725,P=0.46;χ2=1.968,P=0.46,respectively).Conclusion Both EVL and EIS are effective methods for EVB treatment in patients with liver cirrhosis,with comparable efficacy and safety.
Keywords：Esophageal varicesRuptured hemorrhageEndoscopic injection sclerotherapyEndoscopic variceal ligation
Publication Date：2025-02-20
Online Publishing Date：2025-10-31(First online date of this platform, not the publication date of the document)
Pages：5( 53-57 )