Association between parathyroid hormone levels and subclinical myocardial injury:a population-based study
Xing Tuanjie
Yang Kai
Jiang Chenggong
Song Hejian
Abstract：Objective To investigate the association between parathyroid hormone(PTH)and subclinical myocardial injury(SC-MI).Methods Based on data from the 2003-2004 National Health and Nutrition Examination Survey(NHANES),a total of 6,804 adults were included.High-sensitivity cardiac troponin I(hs-cTnI),high-sensitivity cardiac troponin T(hs-cTnT)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)were used as biomarkers of SC-MI.Participants were divided into four groups(Q1-Q4)according to PTH quartiles.One-way analysis of variance(ANOVA)was used to compare the mean levels of three biomarkers among the groups.Multivariable linear regression models were applied to assess the associations between PTH and the biomarkers,adjusting for demographic,metabolic and renal function-related covariates.Stratified analyses were performed by age,sex,body mass index(BMI),serum phosphorus and creatinine levels.Results With increasing PTH levels from Q1 to Q4,the mean levels of hs-cTnI,hs-cTnT and NT-proBNP also increased significantly(ANOVA,P<0.05).Multivariable regression showed that PTH was independently and positively associated with all three biomarkers(hs-cTnI:β=0.024,P=0.003;hs-cTnT:β=0.081,P<0.001;NT-proBNP:β=2.054,P<0.001).These associations remained consistent across subgroups in stratified analysis.Conclusion PTH levels are significantly associated with SC-MI biomarkers,suggesting that PTH may be involved in the pathophysiological process of SC-MI.Further studies are needed to explore the underlying mechanisms and the intervention potential,which may provide new targets for early cardiovascular risk prevention.
Keywords：Parathyroid hormoneSubclinical myocardial injuryTroponinNT-proBNPPopulation-based study
Publication Date：2024-12-20
Online Publishing Date：2025-08-19(First online date of this platform, not the publication date of the document)
Pages：5( 50-54 )