Comparison of efficacy between ultra-liquid iodized oil and conventional iodine in transcatheter arterial chemoembolization for the treatment of unresectable liver cancer
Han Daqian
Li Hao
Kuang Donglin
Liang Chao
Wang Manzhou
Ju Shuguang
Wang Jiacheng
Niu Yangyang
Han Xinwei
Ren Jianzhuang
Duan Xuhua
Abstract：Objective To compare the therapeutic efficacy of ultra-liquid iodized oil and ordinary iodine applied in transcatheter arterial chemoembolization(TACE)operation to treat unresectable liver cancer,and analyze the related factors affecting the patient's prognosis.Methods The data of unresectable hepatocellular carcinoma patients who underwent TACE at the First Affiliated Hospital of Zhengzhou University from January 2012 to December 2017 were retrospectively analyzed.A total of 102 patients were screened and divided into ordinary iodine group(n=50)and ultra-liquid iodized oil group(n=52).The efficacy of the two groups was compared based on the mRECIST evaluation criteria.Preoperative and postoperative liver function indexes and four indexes of liver fibrosis were compared between the two groups.Results In comparison of preoperative and postoperative liver function indexes of patients in the two groups of patients,the differences were not statistically significant(P>0.05).For the four indicators of liver fibrosis in the two groups of patients after surgery,all had different degrees of elevation compared with the preoperative period,and the differences were statistically significant when comparing the two groups(P<0.05).Compared with ordinary iodine,ultra-liquid iodized oil achieved better short-term efficacy and progression-free survival,and reduced the number of TACE treatments.The incidence of adverse effects was comparable between the two treatments,and both aggravated liver fibrosis.Conclusion Compared with ordinary iodine,ultra-liquid iodized oil can provide better protection of liver function and have a lower impact on liver fibrosis.
Keywords：Ultra-liquid iodized oilOrdinary iodineHepatocellular carcinomaHepatic arterial perfusion chemoembolization
Publication Date：2024-10-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 50-56 )