Analysis and management strategies of adverse effects in hepatic arterial infusion chemotherapy treatment for hepatocellular carcinoma
Wu Ying
Zeng Zhenpeng
Du Duanming
Abstract：Hepatic arterial infusion chemotherapy(HAIC)is an important treatment modality for intermediate and advanced hepatocellular carcinoma,while the management of its adverse effects remains a clinical focus.This study systematically analyzed adverse effects data from 11 prospective clinical trials of HAIC and its combination therapies,investigating the characteristics of adverse effects and their management strategies across different treatment regimens.The study found that major adverse effects of HAIC monotherapy included elevated transaminases(45.3%)and thrombocytopenia(35.2%).When combined with targeted therapy,the incidence of nausea(79.8%)and fatigue(75.5%)increased significantly.Triple therapy led to high rates of hypoalbuminemia(79.0%)and elevated transaminases(76.3%).Based on these characteristics,key strategies including individualized treatment planning,optimization of drug administration,early identification and intervention,and multidisciplinary collaboration were proposed.The implementation of these management measures will help improve the safety and efficacy of HAIC treatment and enhance patient outcomes.
Keywords：Hepatic arterial infusion chemotherapyHepatocellular carcinomaAdverse effectsManagement strategyCombination therapy
Publication Date：2024-08-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 43-47 )