Correlation analysis between arachidonic acid and adenosine diphosphate inhibition rates and microembolic infarction after intracranial aneurysm interventional therapy
Mao Lie
Ma Chencheng
Zhang Guangjian
Shen Yuqi
Chang Hanxiao
Lu Hua
Abstract：Objective To evaluate the relationship between arachidonic acid(AA)inhibition rate,adenosine diphosphate(ADP)inhibition rate,and postoperative microembolic infarction after endovascular treatment of intracranial aneurysms.Method A retrospective analysis was conducted on collected data prospectively between December 2021 and November 2023.Logistic regression was used to analyze the relationship between AA and ADP inhibition rates and microembolism,as well as the causes of microembolism.Result Logistic regression analysis showed no significant correlation between AA inhibition rate and micro infarction(OR:1.00,95%CI:0.98～1.02,P=0.988);ADP inhibition rate showed a significant correlation with the occurrence of micro infarction(OR:0.99,95%CI:0.97～1.00,P=0.044),but ADP inhibition rate had no significant dose-dependent effect on the occurrence of micro infarction.Multivariate analysis showed that a decrease in ADP inhibition rate is a significant risk factor for the occurrence of micro infarction(OR:0.98,95%CI:0.96～0.99,P=0.007).Conclusion A decrease in ADP inhibition rate is a significant risk factor for the occurrence of micro infarction.This provides a basis for the prevention of micro infarction and the adjustment of antiplatelet therapy plans.
Keywords：Intracranial aneurysmInterventional therapyadenosine diphosphateBrain infarction
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 14-17 )