Evaluation of WHO/ISUP Pathological Grading of Clear Cell Renal Cell Carcinoma by CT-based Extracellular Volume Fraction
WANG Shubao
LING Shengquan
PAN Yi
LI Zhijian
CHENG Zhecheng
Abstract：Objective:To investigate the value of computed tomography-based extracellular volume fraction(ECV)for preoperative evaluation of WHO/ISUP pathologic grading of clear cell renal cell carcinoma(ccRCC).Methods:Seventy-two patients with ccRCC who underwent postoperative histological confirmation were retrospectively enrolled.All patients underwent preoperative CT scanning of the abdomen and three-phase enhancement scanning according to the WHO/ISUP grading.Grades I and II were categorized as the low-grade group(48 patients)and grades III and IV were categorized as the high-grade group(19 patients).General clinical data of the two groups were collected,and quantitative parameters,including delayed aortic net value added(∆HUAorta),delayed tumor net value added(∆HUtumor)and ECV,were measured and compared,and the diagnostic efficacy of ECV in the pathological grading of ccRCC was evaluated by plotting the receiver operating characteristic curve(ROC).Results:The∆HUtumor and ECV of ccRCC in low-grade group were significantly higher than those in high-grade group.The ROC curves demonstrated that the efficiency of ECV in evaluating WHO/ISUP low-grade ccRCC(AUC:0.834)was higher than that of∆HUtumor(AUC:0.725).Conclusion:CT-based ECV is valuable for the preoperative evaluation of ccRCC pathological grade.
Keywords：computed tomographyextracellular volume fractionclear cell renal cell carcinomaWHO/ISUP classification
Publication Date：2025-09-30
Online Publishing Date：2025-10-28(First online date of this platform, not the publication date of the document)
Pages：6( 959-964 )