Diagnostic Efficacy of Quantitative Computed Tomography in CTD-ILA/ILD
WANG Ke
JI Hanying
HUANG Xiaoqi
PAN Juan
Abstract：Objective:The aim of this study is to evaluate the diagnostic efficacy of quantitative computed tomography(CT)in differentiating between connective tissue disease-associated interstitial lung abnormalities(CTD-ILA)and connective tissue disease-associated interstitial lung disease(CTD-ILD),as well as to establish a screening protocol for connective tissue disease(CTD)patients based on quantitative CT.Methods:A total of 140 patients with CTD-ILD,33 patients with CTD-ILA,and 109 healthy controls were enrolled.Quantitative indices were obtained using the 3D-Slicer software.Results:Significant differences in quantitative CT indices are observed among the groups.ROC analysis shows that the F%,GGO%,SD,and kurtosis are sensitive indicators for differentiating the control group from those with CTD-ILA/ILD.Notably,the best SD is demonstrated in the early diagnosis of both the CTD-ILA(AUC=0.862)and CTD-ILD(AUC=0.923)groups.Further distinguishing between CTD-ILA and CTD-ILD shows the strong discriminatory ability of the SD(AUC=0.649)and F%(AUC=0.617).Multivariable stepwise logistic regression analysis shows that F%,GGO%,SD,and kurtosis are statistically significant in differentiating the control group from the CTD-ILA/ILD groups.Conclusion:Quantitative CT is promising for the early diagnosis of CTD-ILA/ILD.Establishing a CTD screening protocol based on quantitative CT can facilitate precise patient management.
Keywords：quantitative CTconnective tissue diseaseinterstitial lung diseaseinterstitial lung abnormalities
Publication Date：2025-07-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 611-620 )