Computer Tomography Features of Antineutrophil Cytoplasm Antibody-associated Vasculitis-interstitial Lung Disease and Its Correlation with Antineutrophil Cytoplasmic Antibody Concentration
WANG Hongmei
LI Junlin
DONG Yuqing
ZHANG Yueyang
YAO Renhuan
Abstract：This study systematically analyzed the CT imaging features of patients diagnosed with ANCA-associated vasculitis(AAV)-related interstitial lung disease(ILD)at the time of their first diagnosis.The types and distribution characteristics of the lesions and their correlation with laboratory findings were investigated.A retrospective study was conducted on 92 patients with newly diagnosed AAV-ILD.Clinical and CT imaging data were collected.CT imaging data were analyzed qualitatively and quantitatively to evaluate lesion types(e.g.,ground-glass opacities,reticulations,honeycombing,consolidation,and traction bronchiectasis)and their distribution patterns.The severity of the lesions was quantified using a pulmonary fibrosis scoring system,and the correlation between imaging features and laboratory indices was analyzed.AAV-ILD was more commonly observed in elderly male patients.Honeycombing and reticulations were the most common CT-imaging findings,with lesions primarily distributed in the bilateral lower lungs and peripheral regions.AAV-ILD predominantly exhibited a usual interstitial pneumonia(UIP)pattern.A significant positive correlation was also observed between the pulmonary fibrosis score and myeloperoxidase(MPO)concentration and between honeycombing scores and MPO concentration.The CT features of AAV-ILD are unique.The correlation between MPO and pulmonary fibrosis suggests that MPO may serve as a potential biomarker for the progression of pulmonary fibrosis.These findings provide important insights into the imaging characteristics and pathological mechanisms of AAV-ILD.
Keywords：antineutrophil cytoplasmic antibodiesinterstitial lung diseasehigh-resolution CTground-glass opacitieshoneycomb lung
Publication Date：2025-07-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 604-610 )