Pathologic Fracture Predicts for Poor Prognosis in Osteosarcoma for Recurrence and Amputation Based on X-ray
HAO Yun
HE Jin-peng
Abstract：Objective:The significance of pathologic fracture and prognosis for osteosarcoma is still controversial. The aim was to provide a Meta-analysis for pathologic fracture and prognostic features of osteosarcoma patients. Methods:A detailed search was made in MEDLINE, EMBASE and the Web of Knowledge for relevant original articles published in English; methodological quality of the included studies was also assessed. Two reviewers extracted data independently. Studies were pooled and odds ratio (ORs) with corresponding confidence intervals (CIs) were calculated. Results:Pool analysis of 1502 patients from 5 eligible studies was performed. Combined OR of pathologic fracture indicated that pathologic fracture was associated with local recurrence (n=1018 in 4 studies;OR=1.83;95％CI:1.06～3.15;P=0.03) and the limb salvage (n=1502 in 5 studies;OR=1.84;95％CI:1.25～2.72;P=0.002) but not with adequate margin (n=1501 in 5 studies;OR=0.74;95％CI:0.39～1.40;P=0.35) or histological response to neoadjuvant chemotherapy (n=1420 in 4 studies; OR=0.41; 95％ CI:0.98～2.05;P=0.07). Conclusion:The results of this Meta-analysis indicate that a higher risk of local recurrence and amputation were achieved in osteosarcoma patients with pathological fracture than those without pathological fracture. The pathologic fracture is a predictor of poor prognosis in osteosarcoma.
Keywords：osteosarcomapathological fracturerecurrenceamputationprognosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 77-84 )