Medipix-based Spectral Micro-CT
Abstract：Since Hounsfield’s Nobel Prize winning breakthrough decades ago, X-ray CT has been widely applied in the clinical and preclinical applications-producing a huge number of tomographic gray-scale images. However, these images are often insufficient to distinguish crucial differences needed for diagnosis. They have poor soft tissue contrast due to inherent photon-count issues, involving high radiation dose. By physics, the X-ray spectrum is polychromatic, and it is now feasible to obtain multi-energy, spectral, or true-color, CT images. Such spectral images promise powerful new diagnostic information. The emerging Medipix technology promises energy-sensitive, high-resolution, accurate and rapid X-ray detection. In this paper, we will review the recent progress of Medipix-based spectral micro-CT with the emphasis on the results obtained by our team. It includes the state-of-the-art Medipix detector, the system and method of a commercial MARS (Medipix All Resolution System) spectral micro-CT, and the design and color diffusion of a hybrid spectral micro-CT.
Keywords：Multi-energyspectral imagingMedipix detectorMedipix all resolution system (MARS)hybrid spectral micro-CTstatistical iteration reconstructionprinciple component analysis
Publication Date：2012-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：14( 583-596 )