Application of Wells score,D-dimer combined with thromboelastography in acute exacerbation of chronic obstructive pulmonary disease complicated with pulmonary embolism
QIN Hao
LU Wei
GUAN Xiao-yong
Abstract：Objective To explore the value of Wells score and D-dimer combined with thromboelastography(TEG)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with pulmonary embolism.Methods A total of 130 AECOPD patients admitted to the First Affiliated Hospital of Guangxi University of Science and Technology from January 2022 to June 2023 were selected,including 68 males and 62 females,aged(49.45±2.18)years old,with an age range of 20 to 78 years old.According to the results of CT pulmonary angiography,patients were divided into a pulmonary embolism group(n=35)and a non pulmonary embolism group(n=95).The Wells score,D-dimer levels,and TEG parameters[Coulation reaction time(R-time),time of clot formatior(K-time),Comprehensive coagulation index(CI value),maximum amplitude(MA ralue)]were compared between the pulmonary embolism group and the non pulmonary embolism group,and the predictive value of Wells score,D-dimer,TEG,and their combination for AECOPD complicated with pulmonary embolism were analyzed.Results Wells score and D-Dimer content in pulmonary embolism group were higher than those in non pulmonary embolism group;R-time in pulmonary embolism group was lower than that in non pulmonary embolism group;K-time,CI value,MA value in pulmonary embolism group were higher than those in non pulmonary embolism group,the differences were statistically significant(P<0.05).The Well score,D-dimer,TEG and the combination of three tests predicting AECOPD with pulmonary embolism by receiver operator characteristic curve showed that the predictive value of Wells score,D-dimer combined with TEG was higher(P<0.05).Conclusion Wells score,D-dimer combined with TEG in patients with AECOPD complicated with pulmonary embolis can improve the predictive value.
Keywords：Pulmonary embolismWells scoreD-dimerThromboelastographyAcute exacerbation of chronic obstructive pulmonary disease
Publication Date：2025-09-25
Online Publishing Date：2025-11-06(First online date of this platform, not the publication date of the document)
Pages：5( 350-354 )