Treatment of blast-injured sheep using portable extracorporeal membrane oxygenation under simulated transport conditions
LI Hao-ting
CHEN Tao
ZHAI Meng-en
LUO Jian-chao
CHENG Zhi-rong
MA Ji-peng
LIU Yang
LIU Jin-cheng
Abstract：Objective To preliminarily evaluate the efficacy of the Xijing JC-V portable extracorporeal membrane oxygenation(ECMO)system in managing blast-induced thoracic trauma in sheep under simulated transport conditions.Methods A total of 14 healthy adult male Small-tailed Han sheep were randomly allocated to either an ECMO group(n=7)or a conventional mechanical ventilation group(n=7).All animals underwent standardized blast injury modeling via a shock tube.Three simulated transport environmental factors were applied:continuous vibration,temperature variations,and confined space.The ECMO group received rapid deployment of the JC-V portable ECMO system with 24 hours of support,while the conventional group received mechanical ventilation only.Oxygenation index and mean arterial pressure(MAP)were measured pre-treatment and at 24 hours post-treatment.Activated clotting time(ACT)and plasma free hemoglobin were monitored during ECMO treatment.Additional hematological parameters(hemoglobin,white blood cell count,platelet count)were recorded in the ECMO group pre-and post-treatment.System deployment time,flow rate performance,and operational reliability were documented.Results The ECMO group demonstrated significantly superior oxygenation index[(354±26)mmHg vs(263±16)mmHg]and MAP[(66±3)mmHg vs(58±2)mmHg]compared to the conventional group(P<0.05).During ECMO treatment,ACT remained stable at 236±21 s with minimal hemolysis(plasma free hemoglobin:0.23±0.02 g/L).No significant differences were observed in hematological parameters pre-versus post-treatment in the ECMO group(P>0.05).The portable ECMO system was successfully deployed within(6.8±0.4)minutes,maintained stable flow rates(2.04 to 2.31 L/min).Conclusion The JC-V portable ECMO system demonstrates effective support and good safety for managing blast-injured sheep under simulated transport environments.
Keywords：blast injuryportable extracorporeal membrane oxygenation systemtransport conditionslife supportrapid priming
Publication Date：2025-09-25
Online Publishing Date：2025-11-06(First online date of this platform, not the publication date of the document)
Pages：5( 331-335 )