Research Progress on Signal Pathways and Chinese Medicine Intervention in Diabetic Refractory Wounds
Abstract：In recent years, the prevalence of diabetes has increased, and the incidence of diabetic refractory wounds has also shown a continuous upward trend [1]. Diabetic refractory wounds refer to wounds that have not healed within one month, commonly occurring on the lower limbs, often presenting as a chronic inflammatory state, characterized by irregular edges, pale or dark red bases, poor granulation tissue growth, and surrounding skin often accompanied by pigmentation. It is the result of the combined effects of multiple factors such as hyperglycemia, systemic or local vascular lesions, peripheral nerve injury, immune abnormalities, and extracellular matrix disorders, with approximately 15% to 20% of patients facing the risk of amputation [2].
Keywords：Diabetes mellitusRefractory woundsSignaling pathwaysTherapeutic strategiesChinese materia medica
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 237-240 )