Risk Factors and Preventive Interventions for Sepsis Complicating Severe Acute Pancreatitis
Abstract：Objective: To explore the risk factors and preventive interventions for sepsis complicating severe acute pancreatitis (SAP). Methods: A total of 80 SAP patients with sepsis admitted to Hai'an People's Hospital from January 2020 to June 2024 were selected as the sepsis group, including 46 males and 34 females, with an average age of (48.63±5.19) years (age range 20-80 years). Another 100 SAP patients without sepsis during the same period were selected as the non-sepsis group, including 60 males and 40 females, with an average age of (46.89±4.83) years (age range 20-80 years). Clinical data and laboratory indicators were collected and compared, and multivariate logistic regression analysis was used to identify independent risk factors for sepsis in SAP patients. Results: There were statistically significant differences between the two groups in terms of age, pancreatic necrosis extent, ICU admission, mechanical ventilation duration, APACHE II score, platelet count, aspartate aminotransferase, D-dimer, interleukin-6 (IL-6), interleukin-8 (IL-8), prognostic nutritional index (PNI), total cholesterol, and triglycerides (P<0.05). Multivariate analysis showed that high PNI was an independent protective factor for sepsis in SAP patients, while high APACHE II score, pancreatic necrosis extent >50%, long mechanical ventilation duration, high IL-6, and high IL-8 were independent risk factors (P<0.05). Conclusion: The main risk factors for sepsis in SAP patients include pancreatic necrosis extent >50%, prolonged mechanical ventilation, high APACHE II score, high IL-6, high IL-8, and high PNI.
Keywords：Severe acute pancreatitisSepsisInfluencing factorsStrategies for intervention
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 223-226 )