Value of 99Tcm-methoxyisobutylisonitrile myocardial perfusion imaging in evaluating the short-term myocardial repair of myocardial injury caused by heat stroke

LU Guo-xiu; ZHAO Zhi-gang; HAO Shan-hu; LIU Yan-qing; LIANG Jing-jing; ZHANG Guo-xu

doi:10.16048/j.issn.2095-5561.2025.03.08

Abstract：Objective To evaluate the value of 99Tcm-methoxyisobutylisonitrile(MIBI)myocardial perfusion imaging and cardiac ultrasound on short-term myocardial injury caused by heat stroke.Methods A total of 28 patients with myocardial injury caused by heat stroke who underwent cardiac ultrasound and 99Tcm-MIBI myocardial perfusion imaging admitted to the General Hospital of Northem Theater Command from June 2010 to January 2023 were selected,with 23 males and 5 females,aged(35.7±12.5)years old,ranging from 18 to 81 years old.The laboratory test indexes related to myocardial injury[creatine kinase,creatine kinase isoenzyme(CK-MB),myoglobin,N-terminal Pro-B-type natriuretic peptide(NT-ProBNP),amylase,C-reactive protein,high-sensitive cardiac troponin(hs-cTn)],99Tcm-MIBI myocardial perfusion imaging indexes[abnormal myocardial perfusion segments,myocardial perfusion imaging left ventricular ejection fraction(LVEFMPI),summed rest score(SRS)]and ultrasound left ventricular ejection fraction(LVEFUS)recorded and compared within 24 h of onset and at 6 months after treatment.Results At 6 months after treatment,creatine kinase,CK-MB,myoglobin,NT-ProBNP,amylase,C-reactive protein and hs-cTn decreased compared with those within 24 hours of onset,with statisticd significant(P＜0.05).At 6 months after treatment,LVEFUS recovered to(56.32±6.88)％,which was higher than that within 24 hours of onset[(43.00±8.23)％],and the difference was statistically significant(P＜0.05).At 6 months after treatment,myocardial perfusion imaging showed that the number of abnormal myocardial perfusion segments(3.32±1.16)was significantly decreased compared with that within 24 hours of onset(6.82±2.40),and the SRS[(11.93±5.95)points]was significantly decreased compared with that within 24 hours of onset[(21.32±5.68)points],the differences were statistically significant(P＜0.05).NT-ProBNP was positively correlated with the number of abnormal myocardial perfusion segments and SRS,while NT-ProBNP was negatively correlated with LVEFMPI,CRP was negatively correlated with LVEFUS(P＜0.05).Conclusion 99Tcm-MIBI myocardial perfusion imaging may help to identify the injured myocardium that has not been fully repaired in the short-term time window(6 months after treatment),and more directly reflect the myocardial blood flow.