The prognostic value of peripheral blood C-X-C motif chemokine ligand 8 and C-X-C motif chemokine ligand 10 in viral pneumonia patients with acute respiratory distress syndrome
JIANG Ming-ming
MAI Zhi-tao
CHEN Yang
WAN Shan-zhi
DI Qing-guo
Abstract：Objective To explore the prognostic value of peripheral blood C-X-C motif chemokine ligand(CXCL)8 and CXCL10 in patients with viral pneumonia(VP)complicated with acute respiratory distress syndrome(ARDS).Methods A total of 140 VP patients with ARDS admitted to Cangzhou Central Hospital from January 2021 to January 2024 were selected as VP combined with ARDS group,with 86 males and 54 females,aged(60.37±7.85)years old,the age ranging from 31 to 82 years old.A total of 70 patients with isolated VP admitted in the same period were selected as VP group,including 45 males and 25 females,aged(60.24±5.36)years old,the age ranging from 24 to 78 years old.In addition,a total of 70 healthy volunteers who underwent physical examination in Cangzhou Central Hospital during the same period were selected as the healthy group,with 44 males and 26 females,aged(60.33±6.08)years old,the age ranging from 18 to 75 years old.Levels of peripheral blood CXCL8 and CXCL 10 of the healthy group,VP group,and VP combined with ARDS group were measured and compared.Based on the oxygenation index,the patients in the VP combined with ARDS group were divided into mild ARDS[200 mmHg＜oxygenation index≤300 mmHg(1 mmHg=0.133 kPa)],moderate ARDS(100 mmHg＜oxygenation index≤200 mmHg),and severe ARDS(oxygenation index≤100 mmHg),and the levels of peripheral blood CXCL8 and CXCL10 were compared.Multivariate logistic regression was used to analyze the factors influencing in-hospital mortality in VP combined with ARDS patients.Receiver operator characteristic(ROC)curve was drawn to assess the efficacy of peripheral blood CXCL8,CXCL10,and their combination in predicting in-hospital mortality in VP combined with ARDS patients.Results The levels of peripheral blood CXCL8 and CXCL10 in VP group and VP combined with ARDS group were higher than those in healthy group,and the levels of peripheral blood CXCL8 and CXCL10 in VP combined with ARDS group were higher than those in VP group,the differences were statistically significant(P＜0.05).The levels of peripheral blood CXCL8 and CXCL10 of VP patients with severe ARDS were higher than those of VP patients with moderate ARDS and VP patients with mild ARDS,and the levels of peripheral blood CXCL8 and CXCL10 of VP patients with moderate ARDS were higher than those of VP patients with mild ARDS,the differences were statistically significant(P＜0.05).Multivariate logistic regression analysis showed that the number of extrapulmonary organ failures≥2,high CXCL8,and high CXCL10 were independent risk factors for in-hospital mortality in VP combined with ARDS patients,while the high oxygenation index was an independent protective factor(P＜0.05).The ROC curve indicated that the combined evaluation of CXCL8 and CXCL10 had a larger area under the curve for predicting in-hospital mortality in VP combined with ARDS patients compared to peripheral blood CXCL8 and CXCL10 alone,the differences were statistically significant(P＜0.05).Conclusion Elevated levels of peripheral blood CXCL8 and CXCL10 are associated with the severity of VP combined with ARDS and in-hospital mortality.The combination of CXCL8 and CXCL10 provides a more effective prediction of in-hospital mortality in VP combined with ARDS patients.
Keywords：Viral pneumoniaAcute respiratory distress syndromeC-X-C motif chemokine ligand 8C-X-C motif chemokine ligand 10Prognosis
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 107-112 )