Clinical effect of Quzhuhuhuayu Tongfu recipe combined with recombinant tissue plasminogen activator in the treatment of acute ischemic stroke
LIU Xi-jian
LOU Lei
Abstract：Objective To investigate the effect of Quzhuhuhuayutongfu recipe combined with recombinant tissue plasminogen activator(rt-PA)on intravenous thrombolytic therapy for acute ischemic stroke(AIS).Methods A total of 100 patients with wind-phlegm-blocked AIS were selected from the Sanshui Hospital,Foshan Hospital of Traditional Chinese Medicine from January to December 2023,including 55 males and 45 females,aged(57.86±8.27)years old,ranging form 59 to 72 years old.The patient were divided into conventional group(n=50)and observation group(n=50)according to different treatment methods.Both groups were treated with rt-PA intravenous thrombolytic therapy after admission.The observation group was additionally treated with Quzhuohuayu Tongfu prescription on the basis of the conventional group.TCM syndrome score,National Institutes of Health Stroke Scale Neurological Deficit score(NIHSS),modified Rankin Scale score(MRS),Modified Barthel Index Rating Scale(MBI)and total effective rate were compared between the two groups before treatment and 2 weeks after treatment.Results Before treatment,there was no significant difference in TCM syndrome scores,NIHSS scores,MRS Scores and MBI scores between the two groups(P＞0.05).After treatment,all the scores,NIHSS scores and MRS Scores of the two groups were lower than before treatment,and the observation group was lower than the conventional group,with statistical significance(P＜0.05).After treatment,the MBI score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the conventional group,with statistical significance(P＜0.05).The total effective rate of observation group was 94.0%(47/50),which was significantly higher than that of conventional group 76.0%(38/50),and the difference was statistically significant(P＜0.05).Conclusion Quzhuhuhuayu Tongfu prescription combined with rt-PA intravenous thrombolytic therapy for AIS can significantly reduce TCM syndrome score and improve nerve function.
Keywords：Quturuhuayu Tongfu formulaRecombinant tissue plasminogen activatorAcute ischemic stroke
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 383-386 )