Influence of cold environment on the immune function and inflammatory factors after trauma
SUN Qian
WANG Cheng
LU Na
CHI Yang
XIAO Yu-wei
ZHANG He
Abstract：Objective To explore the influence of cold environment on the immune function and inflammatory factors after trauma.Methods A total of 10 New Zealand white rabbits were selected and randomly divided into normal temperature group and low temperature group,with 5 rabbits in each group.Normal temperature group rabbits were placed at 22 to 25℃without additional treatment;low temperature group rabbits were placed at-10 to-15℃for cold stimulation.Clinical symptoms and physiological indicators(body temperature,systolic,diastolic pressure,heart rate and oxygen saturation)were observed at 0,2,4 and 8 h after treatment,and 12 and 24 h after return temperature in normal temperature group and low temperature group.The level of inflammatory factors[interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor α(TNF-α)]and immune function(CD3+,B cells,NK cells,platelet count,white blood cell count)were detected at each time point.Results At 2,4 and 8 h after trauma,the body temperature,heart rate,systolic blood pressure and diastolic blood pressure in low temperature group were lower than the normal temperature group,the differences were statistically significant(P＜0.05).At 12 and 24 h after return temperature,the body temperaturein low temperature group were lower than the normal temperature group,the differences were statistically significant(P＜0.05).At 2,4 and 8 h after trauma,the levels of IL-10 and platelet count in low temperature group were lower than those in the normal temperature group,and the levels of interleukin-6 and tumor necrosis factor-α were higher than those in the normal temperature group,the differences were statistically significant(P＜0.05).At 2,4 and 8 h after trauma,the number of CD3+,B cells and NK cells in low temperature group was significantly less than normal temperature group,and the white blood cell level was higher than normal temperature group,the differences were statistically significant(P＜0.05).Conclusion Cold environment can affect the immune system,and the regulation of the inflammatory response is weakened.
Keywords：Cold environmentTraumaImmune functionInflammatory factors
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 377-382 )