A nomogram prediction model for poor prognosis of mechanical thrombectomy in patients with acute anterior circulation large vessel occlusion
LI Jin-ze
ZHANG Luo-jin
SHI Lin
LI Xiao-wan
ZHANG Li-bo
YANG Ben-qiang
Li Xiao-qiu
DUAN Yang
Abstract：Objective To investigate the prediction of poor prognosis after mechanical thrombectomy of acute anterior circulation great vessel occlusion(ACLVO)by using multi-factor nomography model.Methods A total of 304 ACLVO patients were selected,and patients with 3-month modified Rankin scale(mRS)≤2 were included in the good prognosis group(n=140),and those with mRS＞2 were included in the poor prognosis group(n=164).Independent variables associated with poor prognosis were screened by univariate analysis and multiple Logistic regression analysis,and these variables were included in the nomogram model.Calibration curve was used to evaluate the goodness of fit of the model,receiver operating curve(ROC)to verify the predictive efficacy of the model,and decision curve analysis(DCA)to evaluate the clinical application value of the model.Results Multiple logistic regression analysis showed that age(OR=1.082;95%CI:1.050 to 1.112;P＜0.001),NIHSS score at admission(OR=1.231;95%CI:1.056 to 1.215;P＜0.001)(OR=1.131;95%CI:1.055 to 1.213;P＜0.001),HbA1c(OR=1.401;95%CI:1.158 to 1.694;P＜0.001),and successful vascular recanalization(OR=0.305;95%CI:0.156 to 0.595;P＜0.001)were independent predictors of poor prognosis in ACLVO patients received mechanical thrombectomy.The nomogram prediction model showed good calibration and differentiation capabilities.The ROC analysis showed that combining multiple factors to construct a nomogram prediction model is more effective in predicting poor prognosis after mechanical thrombectomy in ACLVO patients than other single factor models.The DCA also showed that the model has clinical value.Conclusion The combined multi-factor nomogram model can predict the risk of poor prognosis after mechanical thrombectomy in ACLVO patients.
Keywords：Mechanical thrombectomyAcute anterior circulation large vessel occlusionPrognosisNomogram prediction model
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 368-372 )