Effect analysis of long-term mild hypothermia and early enteral nutrition in patients with craniocerebral injury
LIU Wen-wen
CHEN Ji-jun
ZHANG Jun-jie
ZHANG Xiong
Abstract：Objective To investigate the effect of long-term mild hypothermia and early enteral nutrition in patients with craniocerebral injury.Methods A total of 108 patients with craniocerebral injury were selected as the study objects,they were divided into observation group(n=54)and control group(n=54)according to random number table method.Ubiquitin carboxy-terminal hydrolase 1(UCH-L1),glial fibrillary acidic protein(GFAP),CNS specific protein(S100-β),systolic peak blood flow velocity(Vs),average blood flow velocity(Vm),pulse index,albumin,total protein,hemoglobin,malondialdehyde,superoxide dismutase(SOD)and reduced glutathione(GSH)were collected and compared between the two groups before and after treatment.The coma time,30-day survival time,disability rate and mortality of the two groups were observed.Results After treatment,UCH-L1,GFAP,S100-β,pulse index,malondialdehyde and SOD in observation group were lower than those in control group,while GSH,Vs and Vm were higher than those in control group,but lower than those in control group(P＜0.05).There was no significant difference in albumin,total protein and hemoglobin between 2 groups(P＞0.05).The coma time in the observation group was shorter than that in the control group,and the survival time was longer than that in the control group,and the 30 d disability rate and fatality rate were lower than that in the control group(P＜0.05).Conclusion Long-term mild hypothermia combined with early enteral nutrition is beneficial to reduce cerebral nerve injury,improve nutritional status and reduce oxidative stress in patients with craniocerebral injury.
Keywords：Long-term mild hypothermiaEarly enteral nutritionCraniocerebral injury
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 352-356 )