Predictive value of C1q and tumor necrosis factor related protein 3,lipoprotein-associated phospholipase A2,soluble my-eloid cells trigger receptor-1 and sTREM-1 for intrastent restenosis in patients with intracranial artery stenosis
SUO Zhi-chao
LIU Yu-qian
XU Cai-na
YANG Chen
HE Tao
Abstract：Objective To evaluate the predictive value of serum complement-C1q/tumor necrosis factor-related protein-3(CTRP3),lipoprotein associated phospholipase A2(LP-PLA2)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)for intrastent restenosis(ISR)following cranialcarotid artery angioplasty and stenting.Methods 107 cases of in patients undergoing cerebral artery stent angioplasty were selected from Langfang People's Hospital.Patients were divided into ISR group(n=26)and NISR group(n=81)according to whether they developed ISR within 6 months after surgery.The low density lipoprotein cholesterol(LDL-C),the number of stents,the proportion of balloon dilated stents,the degree of stenosis,the degree of residual stenosis,and the levels of CTRP3,Lp-PLA2 and sTREM-1 were compared between the two groups.Results LDL-C,number of stents,proportion of balloon dilated stents,degree of stenosis,residual stenosis degree,Lp-PLA2 and sTREM-1 levels in ISR group were higher than those in NISR group,and the differences were statistically significant(P<0.05).The CTRP3 level in ISR group was lower than that in NISR group,and the difference was statistically significant(P<0.05).The number of stents,the degree of stenosis and residual stenosis,the level of CTRP3 decreased,and the level of Lp-PLA2,LDL-C and sTREM-1 increased were independent risk factors for ISR in patients with cerebrovascular stenosis after angioplasty(P<0.05).The area under the prediction curve of CTRP3,Lp-PLA2,sTREM-1 and the combination were 0.840,0.784,0.809 and 0.899 respectively in patients with cerebrovascular stenosis after craniocerebral angioplasty.The combined prediction value of CTRP3 was significantly higher than that of a single index.Conclusion The decrease of CTRP3 level and the increase of Lp-PLA2 and sTREM-1 level are related to ISR after craniocerebral artery stenting in patients with cerebrovascular stenosis.Combined index detection has certain predictive value for ISR after craniocerebral artery stenting in patients with cerebrovascular stenosis.
Keywords：C1q and tumor necrosis factor related protein 3Lipoprotein-associated phospholipase A2S lipoprotein-associat-ed phospholipase A2AngioplastyIntrastent restenosis
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 277-281 )