Levels of platelet,coagulation function and interleukin-6 in elderly patients with severe community-acquired pneumonia in intensive care unit and their clinical significance

TONG Zhong-man; TONG Min; ZHAO Chen; XIONG Jian

doi:10.16048/j.issn.2095-5561.2024.03.03

Abstract：Objective To investigate the levels of platelet(PLT),coagulation function and serum interleukin-6(IL-6) in elderly patients with severe severe community-acquired pneumonia(CAP) in intensive care unit(ICU),and analyze their clinical significance.Methods A total of 96 elderly patients(age>60 years) with severe CAP admitted to ICU of Leshan Traditional Chinese Medicine Hospital from April 2021 to April 2023 were selected as the severe group,and 76 elderly patients with normal physical examination during the same period were selected as the normal group.According to the survival of patients with severe CAP at 6 months after admission,the patients with severe CAP were divided into survival group(n=58) and death group(n=38).PLT,activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen(FIB) and serum IL-6 expression levels were detected.Spearman correlation analysis was used to analyze the correlation between PLT,IL-6 levels and coagulation function indexes in elderly patients with severe CAP.Receiver operating characteristic ( ROC) curve was used to analyze the value of PLT,IL-6 and coagulation function indexes to predict the prognosis of elderly patients with severe CAP.Results The level of PLT in the severe group was lower than that in the normal group,and the levels of APTT,PT and IL-6 were higher than those in the normal group,with statistical significance(P<0.05).The level of PLT in the death group was lower than that in the survival group,the levels of APTT,PT and IL-6 were higher than those in the survival group,with statistical significance(P<0.05).Spearman correlation analysis showed that PLT was negatively correlated with APTT and PT in ICU elderly patients with severe CAP(r=-0.665,P<0.05;r=-0.528,P<0.05).IL-6 was positively correlated with APTT and PT in ICU elderly patients with severe CAP(r=0.591,P<0.05;r=0.602,P<0.05).ROC curve results showed that the areas under the ROC curves of PLT,IL-6,APTT and PT were 0.949[95％ confidence interval(CI):0.884-0.983,P<0.05],0.874(95％ CI:0.790-0.933,P<0.05),0.840(95％ CI:0.751-0.907,P<0.05) and 0.740(95％ CI:0.640-0.824,P<0.05),respectively.Conclusion PLT,coagulation function indexes(APTT,PT) and IL-6 levels can be used to evaluate the prognosis of elderly patients with severe CAP in ICU.