Effect of albuterol nebulization combined with glucocorticoid regimen on pulmonary ventilatory function and expression of proinflammatory factors in AECOPD patients

ZHANG Lei

doi:10.16048/j.issn.2095-5561.2024.02.12

Abstract：Objective Clinical effect of salbutamol aerosol combined with glucocorticoid in the treatment of acute exacerbation chronic obstructive pulmonary disease (AECOPD). Methods 50 patients with AECOPD were selected as the study objects and divided into hormone group and combination group according to medication methods,with 25 cases in each group. The hormone group was treated with methylprednisolone sodium succinate for injection,and the combined group was treated with salbutamol atomization based on the hormone group. The total effective rate,disease severity before and after treatment,proinflammatory factor level,blood gas index,blood routine,respiratory dynamics and pulmonary ventilation function of the two groups were compared,and the incidence of adverse drug reactions between the two groups were also compared. Results After treatment,the total effective rate of combined group was higher than that of hormone group,and the incidence of adverse reactions was lower than that of hormone group,the difference was statistically significant(P＜0.05). After treatment,acute physiology and chronic health evaluation Ⅱ,clinical COPD qusetionnaire scores,C-reactive protein,procalcitonin,interleukin-6,malondialdehyde,arterial partial pressure of carbon dioxide,mean airway pressure and airway resistance levels decreased in both groups. Glutathione peroxidase,superoxide dismutase,arterial partial oxygen pressure,blood oxygen saturation peak inspiratory pressure,forced vital capacity,forced expiratory volume in the first second and peak respiratory flow rate were all increased,and the changes were more significant in combination group,with statistical significance (P＜0.05). Conclusion Salbutamol aerosol combined with glucocorticoid can effectively treat AECOPD,reduce the severity of the disease,improve the inflammatory state of the body,blood gas indexes and respiratory dynamics indexes,improve lung ventilation function,less adverse reactions,and high safety.