Efficacy of dexmedetomidine combined with propofol in transcatheter aortic valve replacement in elderly patients with severe aortic stenosis

XU Yang; CHEN Xiao-yu; WANG Li

doi:10.16048/j.issn.2095-5561.2024.02.08

Abstract：Objective To investigate the anesthetic effect of dexmedetomidine combined with propofol in transcatheter aortic valve replacement (TAVR) in elderly patients with severe aortic stenosis. Methods A total of 80 patients with severe aortic stenosis un-dergoing TAVR were selected as the study objects and divided into propofol group (P group) and dexmedetomidine combined with propofol group (DP group) by random number table method,with 40 cases in each group. The use of propofol,airway intervention rate,intraoperative access,operation time,recovery time,ICU stay time,postoperative hospital stay,postoperative analgesia rate,hypotension,bradycardia,postoperative anxiety and so on were compared between the two groups. Results The intraoperative propo-fol dosage,incidence of hypotension and airway intervention rate in DP group were significantly lower than those in P group,and the incidence of bradycardia was significantly higher than that in P group,with statistical significance(P＜0.05). The visual simulation scores at rest and exercise at 4,8 and 12 hours in DP group were significantly lower than those in P group,with statistical significance (P＜0.05). The rate of oxycodone usage and anxiety in DP group were significantly lower than those in P group,and the duration of ICU stay and postoperative hospital stay in DP group were significantly shorter than those in P group,with statistical significance (P＜0.05). Conclusion Dexmedetomidine combined with propofol has good anesthetic effect in elderly patients with severe aortic stenosis during TAVR operation,which can reduce the dosage of propofol and intervention of artificial airway,make respiration and hemodynamics more stable,contribute to early postoperative rehabilitation and shorten hospital stay.