Risk factors and preventive strategies of pulmonary fungal infection in 226 patients with emergency ICU

LU Qin-yang; LIU Shan-shou; LUO Heng; AI Mei-mei

doi:10.16048/j.issn.2095-5561.2024.02.02

Abstract：Objective To investigate the risk factors and prevention strategies of pulmonary fungal infection in 226 patients with emergency ICU. Methods Among 226 patients treated in the Emergency ICU of the First Affiliated Hospital of Air Force Military Medical University from March 2021 to June 2023,111 patients had pulmonary fungal infection and 115 patients had non-pul-monary fungal infection. The clinical data of the two groups were collected,the risk factors were analyzed by logistics regression model,and the ROC curve was drawn by the probability value fitted by the regression equation. Results In 111 patients with pul-monary fungal infection,123 strains of fungi were detected,of which 93 strains were Candida alba,accounting for 75.61％. Mul-tivariate Logistic regression showed that diabetes mellitus,duration of use of broad-spectrum antibiotics,types of broad-spectrum antibiotics,duration of glucocorticoid use,mechanical ventilation,hemoglobin (Hb) and serum albumin (ALB) were important influencing factors of pulmonary fungal infection in emergency ICU patients (P＜0.05). ROC analysis showed that the AUC of combined prediction and evaluation of pulmonary fungal infection was 0.992,95％ credibility interval was 0.983～1.000 (P＜0.05),sensitivity was 0.973,specificity was 0.948. Conclusion Candida alba is a common strain of pulmonary fungal infection in emer-gency ICU. Diabetes mellitus,duration of use of broad-spectrum antimicrobials,types of broad-spectrum antimicrobials,duration of use of glucocorticoids,mechanical ventilation,Hb,ALB were important factors affecting pulmonary fungal infection in emer-gency ICU patients.