Anesthetic effect of propofol and isoflurane in pig model of hemorrhagic shock at low temperature

LI Zhi; WANG Qiang; ZHANG Yu-ji; TAO Deng-shun

doi:10.16048/j.issn.2095-5561.2023.05.15

Abstract：Objective To compare the anesthetic effect of propofol intravenous anesthesia and isoflurane inhalation anesthesia in hypothermia hemorrhagic shock pig model.Methods 12 male Bama miniature pigs were selected and divided into two groups with 6 pigs per group by random number method.Group Ⅰ was given intravenous anesthesia with propofol,group Ⅱ was given inhalation anesthesia with isoflurane,and a hemorrhagic shock pig model was established in a cold chamber at-30℃.The changes of heart rate(HR),mean arterial pressure(MAP),pulse oxygen saturation(SPO2)and PH value were continuously monitored.Anes-thesia time and recovery time of spontaneous respiration were recorded.Results There was no significant difference in blood release between the two groups(P>0.05).The time of anesthesia and recovery time of spontaneous respiration in group Ⅱ were shorter than those in group Ⅰ,and the difference was statistically significant(P<0.05).No adverse reactions such as nausea and vomiting occurred in both groups.There was no significant difference in HR,MAP,SPO2 and PH values between the two groups before modeling(P>0.05).After modeling,the MAP of the two groups was significantly lower than that before modeling,while the MAP of the group Ⅱ was higher than that of the group Ⅰ,with statistical significance(P<0.05).After modeling,HR in both groups was significantly higher than that before modeling,while HR in group Ⅱ was lower than that in group Ⅰ,the difference was statistically significant(P<0.05).Conclusion Compared with intravenous anesthesia with propofol,inhalation anesthesia with isoflurane has a more stable anesthetic process,better anesthetic effect,faster postoperative recovery,and better hemodynamic stability.