Correlation between serum 25-hydroxyvitamin D level and osteopenia in elderly patients with chronic kidney disease
FAN Zhong-cheng
WANG Cong-ren
Abstract：Objective To investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and osteopenia in elderly patients with chronic kidney disease(CKD).Methods Participants aged 60 years or older were selected based on data from the National Health and Nutrition Examination Survey(NHANES).Weighted Logistic regression was used to analyze the association between 25(OH)D levels and the risk of osteopeniaby adjusting for possible confounders(age,sex,race,body mass index,recreational exercise,smoking,blood glucose,total cholesterol,triglycerides,hypertension,diabetes,and cardiovascular disease).The modification effect of CKD on this correlation was analyzed.Results A total of 6 851 participants were included in the analysis,including 1 502 patientswith CKD and 5 349 patients without CKD.CKD group had a higher prevalence of osteopenia,the difference was statistically significant(P<0.05).Compared with 25(OH)D deficiency group(levels<50 nmol/L),25(OH)D insufficient group(50-75 nmol/L)and sufficient group(levels≥75 nmol/L)were associated with a lower rate of osteopenia[OR=0.82,95%confidence interval(CI)0.69 to 0.97;OR=0.81,95%CI 0.68 to 0.98)],this association was consistent across CKD and non-CKD populations(P for interaction was 0.292).Conclusion Compared with non-CKD elderly patients,the incidence of osteopenia is more common in elderly patients with CKD.Higher 25(OH)D level is associated with a lower incidence of osteopenia.
Keywords：Elderly peopleOsteopenia25-hydroxyvitamin DChronic kidney disease
Publication Date：2023-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 317-322 )