Temozolomide combined with gamma knife in treatment of lung cancer with brain metastasis
JIAN Qing
KONG Xin
JI Jing
MA Ming
NIU Ting-ting
WANG Fang
LI Chun-tian
Abstract：Objective To explore clinical effect of temozolomide combined with gamma knife in treatment of lung cancer with brain metastasis. Methods A retrospective study was performed on 64 patients with lung cancer with brain metastasis who were admitted from May 2012 to April 2014. Patients were randomly divided into the gamma knife group(n=32) and the combination group(n=32). Patients in the gamma knife group were given gamma knife therapy,choosing 12-25 Gy pe-ripheral dose to perform single gamma knife therapy. Patients in the combination group were given gamma knife therapy combined with oral temozolomide 150 mg/m2 ,once a day in the first 5 days,28 days as a course of treatment. The clinical effect,tumor locally control rate and adverse reactions were compared between the two groups. Results In the combination group,the total effective rate was 81. 3%,tumor locally control rate was 90. 7%,which were significantly higher than those (62. 5% and 84. 4%) in the gamma knife group,the difference between the two groups was statistically significant( P<0. 05). The adverse reactions in the two groups were mainly bone marrow suppression and gastrointestinal reaction,there was no statistically significant difference ( P>0. 05 ) . Conclusion Gamma knife combined with temozolomide in treatment of lung cancer with brain metastasis has better efficacy and safety,which can efficiently control the tumor progression.
Keywords：Lung cancer with brain metastasisGamma knifeTemozolomideEfficacy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 28-31 )