Effect of continuous renal replacement therapy in patients with heat stroke of early stage
HAN Long-fei
JIN Hong-xu
Abstract：Objective To investigate the effect of continuous renal replacement therapy( CRRT) in patients with heat stroke of early stage. Methods A retrospective study was performed on 15 patients with heat stroke received in EICU of The Gen-eral Hospital of Shenyang Military Command from June 2015 to September 2016. All the patients were treated in continuous venous-venous hemofiltration( CVVH) method,the substitution fluid initial temperature was maintained 22℃ ~26℃,lasted for 10~12 hours,then was changed into 36℃ and maintained. The vital signs were monitored,serum urea nitrogen,creati-nine,myoglobin,creatine kinase,alanine aminotransferase,aspartate aminotransferase and arterial lactic acid with take sam-ples of blood before and after CVVH treatment, respectively. Results All 15 patients recovered and discharged. Using CRRT treatment,temperature of the patients was decreased from ( 39. 6 ± 0. 3 )℃ to ( 36. 5 ± 0. 3 )℃( P <0. 05 ) . The mean arterial blood pressure( MAP) ,heart rate( HR) ,APACHEⅡscore and oxygenation index( PaO2/FiO2 ) were signifi-cantly improved compared with those before treatment(P<0. 05). Serum urea nitrogen,creatinine,myoglobin,creatine ki-nase,alanine aminotransferase,aspartate aminotransferase and arterial lactic acid were significantly reduced(P<0. 05). In the process of CRRT treatment,hemodynamic stability,there was no obvious adverse reaction. Conclusion CRRT can ef-fectively reduce the body temperature, remove myoglobin,creatinine and remove inflammatory cytokines and support func-tion of important organs such as liver and kidney. CRRT is safe and effective in the treatment of patients with heat stroke.
Keywords：Heat strokeContinuous renal replacement therapyMultiple organ dysfunction syndrome
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 286-289 )