Meta-analysis of clinical effect by comparing EGFR tyrosine kinase inhibitor (TKI) first-line therapy with chemotherapy
ZONG Shi
Abstract：Objective To compare the efficacy of EGFR tyrosine kinase inhibitors( TKIs) first line therapy with chemo-therapy in NSCLC patients with EGFR gene mutation. Methods All the RCTs comparing TKIs first line therapy with chemotherapy were collected from Chinese and English database by computer. Our Meta-analysis was completed by Review Manager 5. 2 software provided by Cochrane Collaboration. Results Six literatures were included in our Meta-analysis. The HR of OS,PFS and RR of ORR were 0. 95(0. 78 -1. 16),0. 37(0. 27 -0. 52)and 5. 68(3. 16 -10. 19),respectively. Conclusion Comparing with chemotherapy,patients treated with EGFR-TKIs have significant longer PFS and higher ORR. In terms of OS,there is no statistical difference between the two groups. But patients with EGFR-TKIs treatment have a nu-merically longer OS. As a result,EGFR detection should be performed for patients before treated with TKIs.
Keywords：EGFR-TKIs therapyChemotherapyEGFR mutationMeta-analysis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 42-45 )