Advances in immune regulation mechanisms and personalized diagnosis and treatment of trauma-induced sepsis
Zeng Ling
Liu Di
Abstract：Trauma-induced sepsis,a life-threatening syndrome characterized by organ dysfunction resulting from a dysregulated host response to infection,is frequently precipitated by severe trauma or burns.In post-traumatic sepsis,patients experience a"second hit"that further exacerbates immune dysregulation.The immune system un-dergoes continuous dynamic changes,with the potential coexistence of excessive inflammatory responses and immuno-suppression.This immune imbalance poses a significant challenge for precise therapeutic interventions.In recent years,rapid developments have been witnessed in multi-omics technologies and systems medicine,which have ena-bled more accurate identification of biomarkers and molecular targets,facilitating immune phenotyping of sepsis pa-tients,paving the way for personalized diagnostic and therapeutic approaches,and bringing new opportunities for sep-sis research.This review summarizes the latest research progress in the pathogenesis of trauma-induced sepsis with a particular focus on immune dysregulation mechanisms and explores the potential of individualized immunotherapy in promoting novel strategies for sepsis diagnosis and treatment.Furthermore,we discuss how the emerging field of pre-cision medicine,based on sepsis immunology,offers new hope for improving outcomes in sepsis management.By in-tegrating cutting-edge research findings with clinical perspectives,this review aims to provide a comprehensive over-view of the current state and future directions in trauma-induced sepsis research and management.
Keywords：Trauma-induced sepsisImmune dysregulationImmune endotypesPrecision medicineIm-munotherapy
Publication Date：2025-08-15
Online Publishing Date：2025-08-27(First online date of this platform, not the publication date of the document)
Pages：6( 561-566 )