Effect of hyperbaric oxygen combined with early intensive rehabilitation training on outcomes of patients with traumatic brain injuries based on principal component analysis
Li Guoqian
Wang Qiwei
Ouyang Wenxiang
Liu Shasha
Tang Wenjing
Zhu Youdong
Abstract：Objective Principal component analysis was conducted to comprehensively analyze and extract key indicators that can reflect the treatment effect of hyperbaric oxygen combined with early intensive rehabilitation training,so as to form a comprehensive and objective efficacy evaluation system.Methods A total of 101 traumatic brain injury patients treated in our hospital from Jan.2021 to Dec.2022 were selected as study subjects.For all of them,hyperbaric oxygen and early intensive rehabilitation training were conducted.The changed electrophysiological indexes,and scores before and after treatment of National Institute of Health stroke scale(NIHSS),Fugl-Meyer as-sessment(FMA)scale of both upper and lower extremities,Montreal cognitive assessment(MoCA),mini-mental state examination scale(MMSE),and Glasgow coma scale(GCS)were recorded and compared.Results After treatment,the central motor conduction time and cortical latency largely decreased(both P＜0.05);amplitude in-creased(P＜0.05),NIHSS scores decreased(P＜0.05),and upper limb FMA,lower limb FMA,MoCA,MMSE and GCS scores raised(all P＜0.05).The results of the principal component analysis showed that neurocognition and functional recovery,nerve injury and lower limb function,consciousness status or cognitive function and cortical re-sponse were closely related to the therapeutic outcomes of patients.According to the ranking of the importance of each indicator based on the comprehensive weight coefficient,the top three factors were upper limb FMA,MMSE,and cortical latency,with the weight coefficients of their differentials before and after treatment being 0.241,0.198,and 0.134,respectively(all exceeding 0.1),showing a significant impact on patient outcomes.Conclusion Hyperbar-ic oxygen therapy and early intensive rehabilitation training for traumatic brain injury patients can effectively improve the electrophysiological intensity,motor function,cognitive function,and neurological function,shorten the length of hospital stay and comprehensively improve outcomes.
Keywords：Brain injuriestraumaticRehabilitation trainingHyperbaric oxygenation treatmentOut-comes
Publication Date：2025-04-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 284-291 )