Comparison of traumatic related index in serum between minimally invasive and open pedicle screw fixation

ZOU Shu; LV Ren-fa; LIU Jia-qian; SHU Rong-bing; PAN Xiao-feng; WU Gang

doi:10.3969/j.issn.1009-4237.2018.02.015

Abstract：Objective To observe the change of traumatic related index in serum between minimally inva-sive percutaneous pedicle screw fixation and traditional open pedicle screw fixation and investigate its significance. Methods Forty-eight single segment thoracolumbar fracture patients between May 2014 and Oct.2016 were en-rolled in this study.Twenty-three cases were divided into the percutaneous pedicle screw fixation group(minimally invasive group)and 25 cases were divided into the open pedicle screw fixation group(open group).The operative time,intra-operative blood loss,pre-and post-operative Cobb angle,anterior vertebral body height ratio,VAS scores of incision pain and postoperative hospital stay were recorded and compared between the two groups.The serum lev-els of CRP and CK were measured before operation and 24h after operation.The serum levels of IL-6 and IL-10 were measured at preoperation and 2,8,24,48h postoperatively.Results The operative time,intra-operative blood loss, postoperative hospital stay and VAS scores of incision pain were significantly less in the minimally invasive group than those in the open group(P<0.05).The post-operative Cobb angle and anterior vertebralbody height ratio had no significant difference between the two groups(P>0.05).The levels of CK and CRP at 24h after operation in the minimally invasive group were significantly lower than those in the open group(P<0.05).The levels of IL-6 and IL-10 in minimally invasive group were lower than those in the open group at every time point after surgery(P<0.05). Conclusion Minimally invasive percutaneous pedicle screw fixation may significantly reduce tissue injury and sys -temic inflammatory reactions than the traditional open pedicle screw fixation.