Role of soluble urokinase plasminogen activator receptor in predicting postoperative sepsis and predicting prognosis in patients with traumatic colon rupture

MIN An; XIANG He-ping; LI He; GAO Ming; FU Rui; CHENG Jun; WANG Hai-ping; WANG Zhao-hua; WANG Wei; YIN Chun-lin; GE Wei-wei; SUN Yuan-song; JIANG Da-tong

doi:10.3969/j.issn.1009-4237.2018.02.004

Abstract：Objective By dynamically determining the level of soluble urokinase type plasminogen activa-tor receptor(suPAR)in the patients with traumatic colon rupture,to explore the relationship between preoperative serum suPAR level and abdominal secondary infection and the value for severity assessment of these patients'postop-erative serum suPAR for postoperative secondary abdominal infection.Methods Totally 55 patients(37 males and 18 females)with traumatic colon rupture,who were treated in Emergency Surgery of the Second Affiliated Hospital of Anhui Medical University from Mar.2016 to Sep.2017 were selected.And based on whether the patients had sepsis or not,these patients were divided into sepsis group and non-sepsis group.The sepsis group was divided into sepsis group and septic shock group based on the severity of infection.The level of serum suPAR, interleukin-6(IL-6), and C-reactive protein(CRP)were determined and acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score were assessed at the admission,and at 24h,48h,72h after operation.The differences between each set of indicators and these factors'predictive value for abdominal infection of these patients after operation were compared.Results The levels of sepsis group's preoperative and postoperative serum suPAR were significantly higher than those in non-sepsis group((4.63 ±3.19)ng/mL vs.(10.38 ±4.32)ng/mL,P<0.05;(5.21 ±3.98)ng/mL vs. (12.47 ±4.87)ng/mL,P <0.05).The levels of septic shock patients'serum suPAR were also significantly higher than those of sepsis patiens((14.48 ±3.99)ng/mL vs.(8.47 ±3.14)ng/mL,P<0.05).Conclusion (1)The level of serum suPAR in patients with traumatic rupture of colon has certain predictive value for predicting postopera -tive sepsis.(2)The serum level of suPAR in patients after operation has the value in severity assessment for sepsis.