Acute coagulopathy of trauma:molecular mechanisms,diagnosis and management
WEN Ke
LIN Zhe-xuan
HAN Ming
Abstract：Traumatic injury is the second leading cause of death worldwide .High mortality maintains de-spite establishment of regionalized trauma systems and advances in the management of injured patients .And as much as 40％of injury-related mortality is attributed to traumatic coagulopathy .The pathogenesis of acute coagulop-athy of trauma (ACoT) is complicated,owing to multiple factors,including coagulation system ,fibrinolytic system, tissue perfusion,inflammation and endothelium .Therefore,ACoT is not merely a consumptive coagulopathy ,but a systemic imbalance involving multiple factors ,which is understood by cell-molecules based model rather than plasma based model .It is still critical to make a summary about the mechanisms of ACoT .
Keywords：traumacoagulopathyhyperfibrinolysisactivated protein-C
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 72-76 )