Relationships between serum adiponectin,leptin and hip fracture in middle-aged and elderly

LIU Tao; DING Tao; XIE Bin; XUE Jian-li; FENG Peng

doi:10.3969/j.issn.1009-4237.2017.12.008

Abstract：Objective To investigate the relationships between serum adiponectin ,leptin and hip fractures in middle-aged and elderly . Methods Totally 245 hip fracture patients who received treatment in Yan 'an People's Hos-pital from Jan.to Dec.2015 were recruited in our study,with 130 men and 115 women,and the mean age was (64.26 ±6.33) years.A total of 510 non-facture individuals who took health examination in the physical examination center of Yan 'an People's Hospital during the same period were taken as controls ,with 263 men and 247 women,and the mean age was (62.20 ±7.03) years.Serum adiponection and leptin of the 245 patients and 510 controls were meas-ured by radioimmunoassay.Clinical data of the case group and controls were compared ,including age,BMI,systolic blood pressure (SBP),diastolic blood pressure (DBP),smoking,drinking,physical activity,low density lipoprotein cholesterol ( LDL-C) ,adiponection ,and leptin and so on .Logistic regression models were used to estimate the associa-tion between elevated levels of serum adiponection and leptin and risk of hip fracture .Results The age,BMI,SBP, DBP,triglyceride (TG),LDL-C,diponection and leptin of the case group was significantly higher than those of the controls ( P<0.05) ,while the low density lipoprotein cholesterol ( HDL-C) level of the case group was significantly lower than that of the control group (P<0.05).The proportion of people smoking and drinking in the case group was significantly higher than that of the control group (P<0.05).The proportion of people who do physical activity of the case group was significantly lower than that of the control group (P<0.05).Higher levels of serum adiponection and leptin were related to higher risk of hip fracture .The risk rate of fracture in the group with the highest serum adipone-ction and leptin level was 1.4 times than that in the group with the lowest serum adiponection and leptin level .Con-clusion Serum adiponectin and leptin are independently associated with hip fracture .