Clinical value of serum potassium and sodium combined hepatic transaminases in the blunt liver injury
HUANG Chao
ZHANG Kun
JIANG Yi
Abstract：Objective To investigate the clinical application value of serum potassium and sodium com-bined hepatic transaminases in the blunt liver injury .Methods Clinical data of 202 patients with blunt liver and spleen injury admitted between Oct .2003 and Apr.2016 in the Fuzhou General Hospital were reviewed retrospec-tively.According to the presence or absence of liver injury ,they were divided into liver injury group and non-liver in-jury group, with 101 cases in each group.In the liver injury group,53 cases of mild liver injury were taken as the mild liver injury group and 48 cases of severe liver injury were taken as the severe liver injury group .Values of ser-um potassium,sodium,alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in the two groups were detected,and the regression model was established by Logistic regression to draw receiver operating characteristic curve to evaluate the diagnostic value of individual and joint detection indicators .The optimal threshold of ALT and AST in liver injury and serum potassium ,sodium,ALT and AST in severe liver injury were determined by the ROC curve.Results Four metric levels were statistically significant (P<0.01) between non-liver injury group and liver injury group,and were statistically significant (P <0.01) between mild liver injury group and severe liver injury group.AUC of combined detection was greater than single detection for judging the presence or absence of liver injury in the blunt abdominal injury,but the difference was not statistically significant (P>0.05).Prediction rates of ALT alone and combined detection were 89.1% and 94.1% for the presence of liver injury , respectively,and sensitivity and specificity of ALT alone for determination of liver injury were 92.1% and 93.1%, respectively , but combined were 93.1%and 93.1%.AUC of combined detection was greater than single detection for judging the presence or ab -sence of severe liver injury in the blunt liver injury and the difference was statistically significant (P=0.043),predic-tion rates of ALT alone detection were 79.2% and 58.3%, respectively ,but combined were 81.1% and 70.8% for the mild liver injury and severe liver injury ,and sensitivity and specificity of ALT alone for determination of liver inju-ry were 83.3%and 54.7%, respectively,but combined were 66.7%and 94.3%.This study obtained that of the opti-mal threshold of ALT,AST in liver injury were 57.55U/L and 59.20U/L, respectively,and that the optimal threshold of serum potassium,sodium,ALT and AST of severe liver injury were 3.685mmol/L,142.55mmol/L,171.50U/L and 364.00U/L, respectively by the ROC curve assessment .Levels of serum potassium and sodium are negatively correla-ted in mild liver injury and severe liver injury(P=0.005,r=-0.382;P=0.001,r=-0.494),especially significant in severe liver injury .Conclusion Increased liver transaminases are closely related to liver damage .Combined elec-trolytes detection of liver function for clinical identification of whether liver injury is severe has high accuracy ,predict-ability and specificity in the blunt liver injury ,which could be used as one of the initial effective means for early clini-cal judgment of whether blunt liver injury is severe ,so as to provide strong evidence for its clinical treatment .
Keywords：hepatic injuryserum potassiumserum sodiumtransaminases
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 904-910 )