Effect of intra-operative hypothermia therapy on changes of CD4 +and CD8 +level in patients with acute head injury

WANG Shun-fan; YIN Chang-chun; LIU Ping

doi:10.3969/j.issn.1009-4237.2017.11.011

Abstract：Objective To investigate the effect of intra-operative hypothermia on changes of CD 4 +and CD8 +level in patients with acute craniocerebral injury .Methods Eighty patients with craniocerebral hematoma admitted between Jan.2010 and Dec.2015 were randomly divided into observation group (n=40) and control group (n=80).In the observation group,there were 29 males and 11 females,with an average age of 45.2 years (range, 31 to 60 years).The GCS score was 8 to 13 points,with an average of 10.3 points.In the control group,there were 30 males and 10 females,with an average age of 45.3 years (range,31 to 60 years).The GCS score was 8 to 13 points,with an average of 10.4 points.The control group was treated with conventional decompression and the obser-vation group was treated with conventional decompression combined with intra -operative mild hypothermia therapy . The levels of CD4+, CD8 +,CD4 +/CD8 +,the change of immunoglobulins ,ESS,Barthel index and Fugl-Meyer score after intervention were compared between the two groups .Results The levels of CD4 +,CD8 +and CD4 +/CD8 +in the observation group were higher than those in the control group ((35.1 ±2.0)% vs.(26.0 ±0.9)%,(30.6 ± 1.3)%vs.(24.4 ±1.0)%,1.9 ±0.3 vs.1.6 ±0.2,P<0.05),and the levels of IgM,IgG and IgA in the obser-vation group were significantly higher than those in the control group (1.60 ±0.03 vs.1.32 ±0.02,9.52 ±0.12 vs. 8.84 ±0.10,3.91 ±0.20 vs.1.83 ±0.15,P<0.05).The ESS,Barthel index and Fugl-Meyer score in the obser-vation group were higher than those in the control group (P<0.05).Conclusion Mild-hypothermia can reduce the influence of surgery on the immune function in patients with craniocerebral trauma ,promote the recovery of nerv-ous system and improve the quality of life and limb movement .