Influence of repeated use of tranexamic acid on blood loss and security in patients with primary unilateral total knee arthroplasty
GUO Huan-lai
YANG Jian-xiang
ZHAO Jie
FAN Yan-mei
WU Hong-yang
Abstract：Objective To explore the effect of repeated use of tranexamic acid on blood loss and security in patients with primary unilateral total knee arthroplasty(TKA).Methods Totally 138 patients with traumatic arthritis who received TKA in the Second Hospital of Bazhou City from Jan.2015 to May 2016 were enrolled in this study,and were assigned randomly to control 1 group,control 2 group and the observation group according to the number list method,with 46 cases in each group.The patients received 15 mg /kg TXA by intravenous infusion before operation in control 1 group,received 15 mg/kg TXA by intravenous infusion before tourniquet release in control 2 group,received 15 mg/kg TXA before tourniquet release and at 3h after operation respectively in the observation group.Total blood loss,postoperative blood loss via drainage,hidden blood loss,postoperative Hb level,allogeneic blood transfusion rate,incidence of postoperative deep vein thrombosis and pulmonary embolism were observed and compared in three groups.Results The total blood loss ((715.0±197.6)mL) and postoperative blood loss via drainage ((117.53±46.35)mL)in the observation group were less than those in control 1 group((823.2±186.5)mL,(230.61±43.09)mL) and in control 2 group((926.7±206.3)mL,(310.98±73.09)mL),while the postoperative Hb level ((113.7±14.6)g/L) was higher than that in control 1 group((94.9±13.9)g/L) and in control 2 group((92.6±11.3)g/L),and the differences were statistically significant(P＜0.05).The total blood loss and postoperative blood loss via drainage in control 1 group were less than those in control 2 group,and the differences were statistically significant(P＜0.05).The difference of rates of allogeneic blood transfusion and postoperative vascular embolization was not statistically significant(P＞0.05).Conclusion Compared with application of a single dose of 15 mg /kg TXA before operation and tourniquet release,postoperatively repeated use of TXA can effectively reduce the blood loss,and does not increase the risk of vascular embolization.
Keywords：total knee arthroplastytranexamic acidblood loss volume
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 681-684 )