Significance of contrast-enhanced ultrasound and serum liver enzyme levels in the classification of liver injury
BI Jie
HU Jia-yin
TIAN Meng
LI Tao
Abstract：Objective To investigate the value and significance of contrast-enhanced ultrasound (CEUS) and serum liver enzyme levels in the diagnosis and classification of blunt liver injury. Methods Twenty rabbits of (2.15±0.23)kg were made into blunt liver injury models and were performed contrast-enhanced computed tomography (CECT), CEUS and serum liver enzyme assay.Venous blood was drawn for serum liver enzyme assay.According to AAST scale, the degree of liver trauma was evaluated, then result of CEUS and CECT was analyzed using Spearman's correlation analysis, whereas result of serum liver enzyme and CECT was analyzed using Pearson's correlation analysis. Results According to AAST scale, the CEUS and CECT were highly consistent with the classification of liver injury.Coefficient of Spearman's rank correlation was 0.888 (P<0.0001), and Kappa value was 0.71.AST and LDH levels, as well as AST/ALT ratio were positively correlated with the grade of liver injury, and the coefficients of Pearson correlation were 0.664 (P=0.0014), 0.704 (P=0.0005) and 0.503 (P=0.024), respectively.GGT level was statistically negatively correlated with the grade of liver injury (r =-0.467, P=0.038). Conclusion CEUS and serum liver enzyme have high consistency with CECT both in the detection and grading of liver injury.It can be used as a tool for the diagnosis and monitor in the treatment of liver injury.
Keywords：liver injurycontrast ultrasoundliver enzyme levelgrademodel
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 598-602 )