Effect of central venous pressure on septic shock induced acute kidney injury
WANG Yan-jun
GAO Rui
JIA Wen-yuan
ZHANG Song-tao
ZHAO Wei
LIU Zhuo
YIN Wen
Abstract：Objective To explore the correlation between central venous pressure (CVP) on septic shock induced by acute kidney injury (AKI). Methods Patients diagnosed with septic shock admitted to emergency department of Xijing Hospital (Xi'an) between Jan.2012 and Jan.2015 were retrospectively studied.A total of 138 patients with septic shock were included, and they were divided into low central venous pressure (LCVP) group and high central venous pressure (HCVP) group.The death rate, incidence of AKI, and hemodynamics indexes were measured.The correlation between CVP and AKI was analyzed by SPSS. Results While there was a significant difference in the CVP between the two groups (P<0.01), other physiological and biochemical indexes (age, Scr) were not significantly different.The morbidity of AKI was higher in HCVP group (n=59) than LCVP group (31), χ2=8.12,P<0.05.Moreover, the number of AKIN3 was significantly more in HCVP group (n=42) than LCVP group (n=13, χ2=8.12,P<0.05).During the treatment process, there was no significant difference in the application of norepinephring and dobutamine.The death rate was also higher in HCVP group(48.0%) than LCVP group(30.2%, χ2=3.93,P<0.05).Correlation analysis showed that CVP and the death rate of AKI were positively correlated (r=0.80,P<0.01). Conclusion High CVP increases the morbidity and mortality of AKI.Decreased CVP may reduce mortality in septic shock-induced AKI.
Keywords：kidney injurycentral venous pressureshock
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 566-569 )