The effect of intravenous zoledronic acid and calcitonin on the elderly with osteoporotic intertrochanteric fractures

SONG Bi-hui

doi:10.3969/j.issn.1009-4237.2017.03.012

Abstract：Objective To compare the effect of zoledronic acid and calcitonin on the elderly with osteoporotic intertrochanteric fractures.Methods A retrospective analysis was performed among 260 patients using closed reduction and intramedullary nail fixation for the treatment of osteoporotic intertrochanteric fracture.Group A with 127 cases were taking calcitonin and group B with 133 patients were taking zoledronic acid.Fracture healing time after surgery,Harris score 1 year after surgery,VAS score,bone density of lumbar spine and hip 1 week and 1 year after surgery of the two groups were analyzed.Results Fracture healing time after surgery of group A and group B were 103±28.7 days and 104±29.8 days(P>0.05),respectively.Harris score 1 year after surgery[(68.87±4.78) vs.(69.21±4.67)],VAS score[(0.34±0.37) vs.(0.33±0.38)] and bone density of lumbar spine and hip 1 week after surgery [(0.77±0.06)vs.(0.76±0.05)g/cm2] of two groups were not significantly different(P>0.05).Bone density of lumbar spine and hip 1 year after surgery of two group was significantly different[(0.78±0.05)vs.(0.80±0.05)g/cm2,P<0.05).There was no significant difference of bone density of lumbar spine and hip 1 week and 1 year after surgery in group A(PP>0.05).There was significant difference of bone density of lumbar spine and hip 1 week and 1 year after surgery in group B(P<0.05),and after 1 year the bone density of the patients in group B was better than that of group A(P<0.05).Conclusion The effect of intravenous zoledronic acid and calcitonin on the elderly with osteoporotic intertrochanteric fractures is not significantly different in short term.Zoledronic acid is much more conducive to the improvement of bone density in long period after surgery.