Experimental study of antibiotics/three calcium phosphate/porous silk fibroin scaffold repairing rabbit radial bone defect
LIU Xin-wei
LIU Yun-en
ZHANG Yu-biao
HOU Ming-xiao
ZHAO Yong
ZHOU Da-peng
XIANG Liang-bi
Abstract：Objective To investigate the effect of antibiotics/three calcium phosphate/porous silk fibroin scaffold repairing rabbit radial bone defect .Methods Regenerated silk fibroin capsules for artificial bone repair materials were prepared .Sixteen adult white rabbits were randomly divided into group A ( SF+beta TCP for repai-ring bone defect ) and group B ( SF+beta TCP+vancomycin for repairing bone defect ) .There were 8 rabbits ( 16 radius) in each group .Radial bone defect model was constructed after implanting materials .The rabbits were exe-cuted at 28,56,84 and 112 days postoperatively to observe the general situation .If infection occurred ,rabbits were withdrawn from the observation .Half of the rabbits were executed after 84 and 112 days to observe the histologic findings of bone healing .Results Four rabbits in group A (8 cases of radius ) occurred infection about 6 to 7 days after operation .Cases in group B were without infection ,The incidence of infection in group A was significantly high-er than that in group B(χ2 =8.167,P=0.004).Bone repair effect in 2 rabbits in group A(4 cases of radius) and 3 rabbits in group B(6 cases of radius) was satisfactory.There was no significant difference between the two groups in the histological observation .Histological observation can see the new bone , a small amount of β-three calcium phosphate and silk fibroin scaffold residues ,but 1 rabbit in group B was with bilateral false joints after 84 days.Af-ter 112 days,bone repair effect in 1 rabbit in group A(2 cases of radius) and 4 rabbits in group B(8 cases of radi-us) was satisfactory,Histological section observation result was similar to that after 84 days and no significant differ-ence between the two groups ,but more new bone mass was seen ,only 1 rabbits in group A occurred buckling spasm . Conclusion Antibiotics/three calcium phosphate/porous silk fibroin scaffold has good histocompatibility .Porous structure allows peripheral stem cells ,including osteoblasts to move within the tube wall .Also,it contains antibiot-ics.All these are good for bone defect repair and infection prevention .
Keywords：radiusbone defectantibioticsβ-three calcium phosphatesilk fibroinrepairrabbits
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 114-117 )